Publications

 

  1. Zheng W, Umitsu M, Jagan I, Tran CW, Ishiyama N, BeGora M, Araki K, Ohashi PS, Ikura M, Muthuswamy S.K. (2016) An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function. Nat Cell Biol. 2016 Oct 3(In Press).
  2. Milano DF, Natividad RJ, Saito Y, Luo CY, Muthuswamy SK, Asthagiri AR.(2016)Positive Quantitative Relationship between EMT and Contact-Initiated Sliding on Fiber-like Tracks.Biophys J. 2016 Oct 4;111(7):1569-1574
  3. Baker L, BeGora M, Au Yeung F, Feigin ME, Rosenberg AZ, Lowe SW, Kislinger T, Muthuswamy SK. (2016)Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland.J Cell Sci. 2016 Jun 15;129(12):2307-15
  4. Milano DF, Ngai NA, Muthuswamy SK, Asthagiri AR. (2016)Regulators of Metastasis Modulate the Migratory Response to Cell Contact under Spatial Confinement.Biophys J. 2016 Apr 26;110(8):1886-95.
  5. Huang, L., Holtzinger A., Jagan, I., BeGora, M., Lohse, I., Ngai, N., Nostro, C., Wang, R., Muthuswamy, L.B., Crawford, H.C., Cheryl Arrowsmith, C., Kalloger, S.E., Renouf, D.J., Connor, A., Cleary, S., Schaeffer, D.F., Roehrl, M., Tsao, M., Gallinger, S., Keller, G., and Muthuswamy, S.K. (2015) Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids. Nat Med. 2015 Nov;21(11):1364-71.
  6. Ramesh M, Krishnan N, Muthuswamy SK, Tonks NK. A Novel Phosphatidic Acid-Protein Tyrosine Phosphatase D2 Axis is Essential for ERBB2 Signaling in Mammary Epithelial Cells. J Biol Chem. 2015 Feb 13. pii: jbc.M114.627968
  7. Krishnan N, Koveal D, Miller DH, Xue B, Akshinthala SD, Kragelj J, Jensen MR, Gauss CM, Page R, Blackledge M, Muthuswamy SK, Peti W, Tonks NK. Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Nat Chem Biol. 2014 Jul;10(7):558-66
  8. Feigin, ME, Xue, B, Hammell, M, Muthuswamy, SK. The orphan G-protein coupled receptor GPR161 is an oncogene in triple negative breast cancer. PNAS. 2014 Mar 18;111(11):4191-6.
  9. Feigin, ME, Akshinthala, D, Araki, K, Rosenberg, AZ, Muthuswamy, LB, Martin, B, Lehmann, BD, Berman, HK, Pietenpol, JA, Cardiff, RD and Muthuswamy, SK. Mislocalization of the cell polarity protein Scribble promotes mammary tumorigenesis and is associated with basal breast cancer. Cancer Res. 2014 Jun 1;74(11):3180-94.
  10. Xue, B, Krishnamurthy, K, Allred, CA, Muthuswamy, SK. Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nat Cell Biol. 2013 Feb;15(2):189-200.
  11. Wang, H, Lacoche, S, Huang, L, Xue, B, Muthuswamy, SK. Rotational motion during three-dimensional morphogenesis of mammary epithelial acini relates to laminin matrix assemble, Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):163-8. doi: 10.1073/pnas.1201141110
  12. Yang Z, Xue B, Umitsu M, Ikura M, Muthuswamy SK, Neel BG. The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold. Mol Cell. 2012 Aug 10;47(3):469-83. doi: 10.1016/j.molcel.2012.06.037.
  13. Muthuswamy SK. Autocrine prolactin: an emerging market for homegrown (prolactin) despite the imports. Genes Dev. 2012 Oct 15;26(20):2253-8. doi: 10.1101
  14. Muthuswamy SK, Xue B. Cell polarity as a regulator of cancer cell behavior plasticity. Annu Rev Cell Dev Biol. 2012;28:599-625. doi: 10.1146/annurev-cellbio-092910-154244. Epub 2012 Aug 6.
  15. Yu M, Lin G, Arshadi N, Kalatskaya I, Xue B, Haider S, Nguyen F, Boutros PC, Elson A, Muthuswamy LB, Tonks NK, Muthuswamy SK. Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation. Mol Cell Biol. 2012 Oct;32(19):3913-24.
  16. Chatterjee S, Seifried L, Feigin ME, Gibbons DL, Scuoppo C, Lin W, Rizvi ZH, Lind E, Dissanayake D, Kurie J, Ohashi P, Muthuswamy SK. Dysregulation of cell polarity proteins synergize with oncogenes or the microenvironment to induce invasive behavior in epithelial cells. PL0S One. 2012;7(4):e34343. Epub 2012 Apr 18.
  17. Anczuków O, Rosenberg AZ, Akerman M, Das S, Zhan L, Karni R, Muthuswamy SK, Krainer AR., The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nat Struct Mol Biol. 2012 Jan 15;19(2):220-8.
  18. Lin G, Aranda V, Muthuswamy SK, Tonks NK., Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the ‘PTP-ome’. Genes Dev. 2011 Jul 1;25(13):1412-25.
  19. Simpson DR, Yu M, Zheng S, Zhao Z, Muthuswamy SK, Tansey WP. Epithelial cell organization suppresses Myc function by attenuating Myc expression. Cancer Res. 2011 Jun 1;71(11):3822-30, Epub 2011 May 24
  20. Muthuswamy SK. Trastuzumab resistance: all roads lead to SRC. Nat Med. 2011 Apr;17(4):416-8.
  21. Keys WM, Pecoraro M, Aranda V, Vernersson-Lindahl E, Li W, Vogel H, Guo X, Garcia EL, Michurina TV, Enikolopov G, Muthuswamy SK, Mills AA. ΔNp63α Is an Oncogene that Targets Chromatin Remodeler Lsh to Drive Skin Stem Cell Proliferation and Tumorigenesis. Cell Stem Cell. 2011 Feb 4;8(2):164-76.
  22. Muthuswamy SK. 3D culture reveals a signaling network. Breast Cancer Res. 2011 Jan 27;13(1):103. Epub adhead of print.
  23.  Arias-Romero LE, Villamar-Cruz O, Pacheco A, Kosoff R, Huang M, Muthuswamy SK, Chernoff J. A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells. Oncogene. 2010 Oct 28;29(43):5839-49 Epub Aug 16.
  24. Cabodi S, Tinnirello A, Bisaro B, Tornillo G, Camacho-Leal MD, Forni G, Cojoca R, Iezzi M, Amici A, Montani M, Eva A, Di Stefano P, Muthuswamy SK, Tarone G, Turco E, Defilippi P. p130Cas is an essential transducer element in ErbB2 transformation. FASEB J. 2010 Oct;24(10):3796-808. Epub May 26.
  25. Ling C, Zuo D, Xue B, Muthuswamy S, Muller WJ., A novel role for 14-3-3σ in regulating epithelial cell polarity. Genes Dev. 2010 May;24(9);947-956.
  26. Huang L, Muthuswamy S.K. Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators. Curr Opin Genet Dev. 2010 Feb;20(1):41-50. Epub 2010 Jan 21.
  27. Muthuswamy S. A new road map for cancer. Interview by Caitlin Sedwick. J Cell Biol. 2009 Oct 19;187(2):152-3
  28. Lucs AV, Muller WJ, Muthuswamy SK. Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and distruption of cell polarity. Oncogene. 2010 Jan 14;29(2):174-87. Epub 2009 Oct 12.
  29. Feigin ME, Muthuswamy SK. Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Curr Opin Cell Biol, 2009 Oct;21(5):694-700. Epub 2009 Sep 2.
  30. Muthuswamy SK. A new tumor suppressor that regulates tissue architecture. PLoS Med. 2009 May 26;6(5):e1000073. Epub 2009 May 5.
  31. Silva JM, Ezhkova E, Silva J, Heart S, Castillo M, Campos Y, Castro V, Bonilla F, Cordon-Cardo C, Muthuswamy SK, Powers S, Fuchs E, Hannon GJ. Cyfip1 is a putative invasion suppressor in epithelial cancers. Cell. 2009 Jun 12;137(6):1047-61.
  32. Zavadil J, Haley J, Kalluri R, Muthuswamy SK, Thompson E. Epithelial-mesenchymal transition. Cancer Res, 2008 Dec 1;68(23):9574-7.
  33. Zhan L, Rosenberg A, Bergami KC, Yu M, Zuan Z, Jaffe AB, Allred C, Muthuswamy S.K. Deregulation of Scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell 2008 Nov 28; 135(5):865-78.
    30. Aranda V, Nolan ME, Muthuswamy SK. Par complex in cancer: a regulator of normal cell polarity joins the dark side. Oncogene, 2008 Nov 24;27(55):6878-87.
  34.  Feigin ME, Muthuswamy SK. ErbB receptors and cell polarity: new pathways and paradigms for understanding cell migration and invasion. Exp Cell Res. 2009 Feb 15;315(4):707-16. Epub 2008 Nov 5.
  35. Nolan ME, Aranda V, Lee S, Lakshmi B, Basu S, Allred DC, Muthuswamy SK. The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer. Cancer Res. 2008 Oct 15;68(20):8201-9.
  36. Xiang B, Chatti K, Qiu H, Lakshmi B, Krasnitz A, Hicks J, Yu M, Miller WT, Muthuswamy SK. Brk is coamplified with ErbB2 to promote proliferation in breast cancer. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12463-8. Epub 2008 Aug 21.
  37.  Guix M, Granja Nde M, Meszoely I, Adkins TB, Wieman BM, Frierson KE, Sanchez V, Sanders ME, Grau AM, Mayer IA, Pestano G, Shyr Y, Muthuswamy S, Calvo B, Krontiras H, Krop IE, Kelley MC, Arteaga CL., Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers. J Clin Oncol. 2008 Feb 20;26(6):897-906. Epub 2008 Jan 7.
  38.  Ibarra I, Erlich Y, Muthuswamy SK, Sachidanandam R, Hannon GJ. A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells. Genes Dev. 2007 Dec 15;21(24):3238-43.
  39. Tonks NK, Muthuswamy SK. A brake becomes an accelerator: PTP1B—a new therapeutic target for breast cancer. Cancer Cell. 2007 Mar;11(3):214-6.
  40.  Muthuswamy, S.K., ErbB2 makes beta 4 integrin an accomplice in tumorigenesis. Cell, 126(3): p. 443-5, 2006.
  41. Reginato, M.J. and Muthuswamy, S.K., Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis. J Mammary Gland Biol Neoplasia, 11(3-4): p. 205-11, 2006.
  42.  Aranda, V., Haire, T., Nolan, M.E., Calarco, J.P., Rosenberg, A.Z., Fawcett, J.P., Pawson, T., and Muthuswamy, S.K., Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nat Cell Biol, 8(11): p. 1235-45, 2006.
  43. Wang, S.E., Narasanna, A., Perez-Torres, M., Xiang, B., Wu, F.Y., Yang, S., Carpenter, G., Gazdar, A.F., Muthuswamy, S.K., and Arteaga, C.L., HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell, 10(1): p. 25-38, 2006.
  44. Zhan, L., Xiang, B., and Muthuswamy, S.K., Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors. Cancer Res, 66(10): p. 5201-8, 2006.
  45.  Xiang, B. and Muthuswamy, S.K., Using three-dimensional acinar structures for molecular and cell biological assays. Methods Enzymol, 406: p. 692-701, 2006.
  46. Reginato, M.J., Mills, K.R., Becker, E.B., Lynch, D.K., Bonni, A., Muthuswamy, S.K., and Brugge, J.S., Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Mol Cell Biol, 25(11): p. 4591-601, 2005.
  47.  Seton-Rogers, S.E., Lu, Y., Hines, L.M., Koundinya, M., LaBaer, J., Muthuswamy, S.K., and Brugge, J.S., Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells. Proc. Natl. Acad. Sci. USA 101:1257-1262, 2004.
  48. Bill, H.M., Knudsen, B., Moores, S.L., Muthuswamy, S.K., Rao, V.R., Brugge, J.S., and Miranti, C.K., Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Mol Cell Biol, 24(19): p. 8586-99, 2004.
  49. Debnath, J., Muthuswamy, S.K., Brugge, J.S., Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30:256-268, 2003.
  50. Reginato, M.J., Mills, K.R., Paulus, J.K., Lynch, D.K., Lynch, D.K., Sgroi, D.C., Debnath, J., Muthuswamy, S.K., Brugge, J.S., Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol. 5:733-740, 2003.
  51. Debnath, J., Mills, K.R., Collines, N.L., Reginato, M.J., Muthuswamy, S.K. and Brugge, J.S., The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 111:29-40, 2002.
  52. Muthuswamy, S.K., Li, D., Lelivere, S., Bissell, M. and Brugge, J.S., ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat. Cell Biol 3: 785-792, 2001.
  53. Moulder, S.L., Yakes, F.M., Muthuswamy, S.K., Bianco, R., Simpson, J.F. and Arteaga, C.L., Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu(erbB2)-overexpressing breast cancer cells in vitro and in vivo. Cancer Res. 61:8887-8895, 2001.
  54. Muthuswamy, S.K., Gilman, M. and Brugge, J.S., Controlled dimerization of ErbB receptor provides evidence for differential signaling by homo- and heterodimers. Mol. Cell. Biol. 19: 6845-6857, 1999.
  55. Webster, M.A., Hutchinson, J.H., Raugh, M.J., Muthuswamy, S.K., Martina Anton, M., Tortorice, C.G., Cardiff, R.D., Graham, F.L., Hassell, J.A. and Muller, W.J., Requirement for both Shc and phosphatidylinositol 3’ kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol. Cell. Biol. 18: 2344-2359, 1998.
  56. Muller, W.J., Arteaga, C.L., Muthuswamy, S.K., Siegel, P.M., Webster, M.A., Cardiff, R.A., Meise, K.S., Li, F., Halter, S.A. and Coffey, R.J., Synergistic interaction of the Neu protooncogene product and transforming growth factor alpha in the marry epithelium of transgenic mice. Mol. Cell. Biol. 16: 5726-5736, 1996.
  57. Muthuswamy, S.K. and Muller, W.J., Activation of Src family kinase in Neu-induced mammary tumors correlates with their association with distinct sets of tyrosine phosphorylated proteins in vivo. Oncogene 11: 1801-1810, 1995.
  58. Muthuswamy, S.K. and Muller, W.J., Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor. Oncogene 11: 271-279, 1995.
  59. Muthuswamy, S.K., Siegel, P.S., Dankort, D.L., Webster, M.A. and Muller, W.J., Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity. Mol. Cell. Biol. 14: 735-743, 1994
  60. Guy, C.T.*, Muthuswamy, S.K.*, Cardiff, R.D., Soriano, P. and Muller, W.J., Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Gene Dev. 8: 23-32. 1994.* Co-first author.
  61. Muthuswamy, S.K., Muller W.J., Activation of the Src family of tyrosine kinases in mammary tumorigenesis. Adv. Cancer Res. 64:11-23, 1994.
  62. Mymryk, J.S., Oakes, J.D., Muthuswamy, S.K., D’Amico, P., Bayley, S.T. and Lee, R.W.H., Disruption of coordinate expression of muscle gene in a transfected BC3H1 myoblast cell line producing a low level of the adenovirus E1A transforming protein. Biochem. Cell. Biol. 70: 1268-1276, 1992.